What Are the Benefits of Taking CBD Oil? CBD can interact negatively with certain medications. These include benzodiazepine tranquilizers, such as Klonopin (clonazepam) as well as anti-immunosuppressants such as Sandimmune(cyclosporine), and benzodiazepine serotonins. CBD can also increase the levels of blood thinners, such as warfarin. Early research suggests that